CYP11A1 Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone, the precursor of most steroid hormones. Belongs to the cytochrome P450 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.15.6; Lipid Metabolism - C21-steroid hormone; Mitochondrial; Oxidoreductase
Cellular Component:  mitochondrial inner membrane; mitochondrion
Molecular Function:  cholesterol monooxygenase (side-chain-cleaving) activity; heme binding; iron ion binding
Biological Process:  C21-steroid hormone biosynthetic process; cholesterol metabolic process; oxidation-reduction process; vitamin D metabolic process
Reference #:  P00189 (UniProtKB)
Alt. Names/Synonyms: cholesterol desmolase; cholesterol side-chain cleavage enzyme; Cholesterol side-chain cleavage enzyme, mitochondrial; CP11A; CYP11A; CYP11A1; CYPXIA1; cytochrome P450 11A1 mitochondrial; P450(scc)
Gene Symbols: CYP11A1
Molecular weight: 60,333 Da
Basal Isoelectric point: 8.87  Predict pI for various phosphorylation states
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CYP11A1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene