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CYP11A1
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone, the precursor of most steroid hormones. Belongs to the cytochrome P450 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.14.15.6; Lipid Metabolism - C21-steroid hormone; Mitochondrial; Oxidoreductase |
| Chromosomal Location of human Ortholog: 15q24.1 |
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Cellular Component:
mitochondrial inner membrane; mitochondrial matrix; mitochondrion
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Molecular Function:
cholesterol monooxygenase (side-chain-cleaving) activity; heme binding; iron ion binding; protein binding
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Biological Process:
C21-steroid hormone biosynthetic process; cellular response to peptide hormone stimulus; cholesterol metabolic process; cortisol metabolic process; glucocorticoid biosynthetic process; sterol metabolic process; vitamin D metabolic process
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Disease: Adrenal Insufficiency, Congenital, With 46,xy Sex Reversal, Partial Or Complete
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Reference #:
P05108
(UniProtKB)
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Alt. Names/Synonyms: cholesterol 20-22 desmolase; Cholesterol desmolase; cholesterol monooxygenase (side-chain cleaving); Cholesterol side-chain cleavage enzyme, mitochondrial; CP11A; CYP11A; CYP11A1; CYPXIA1; Cytochrome P450 11A1; cytochrome P450 family 11 subfamily A member 1; cytochrome P450 family 11 subfamily A polypeptide 1; Cytochrome P450(scc); cytochrome P450, family 11, subfamily A, polypeptide 1; cytochrome P450, subfamily XIA (cholesterol side chain cleavage); cytochrome P450C11A1; P450SCC; steroid 20-22-lyase
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Gene Symbols: CYP11A1
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Molecular weight:
60,102 Da
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Basal Isoelectric point:
8.89
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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