CYP11A1 Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone, the precursor of most steroid hormones. Belongs to the cytochrome P450 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - C21-steroid hormone; Mitochondrial; Oxidoreductase
Chromosomal Location of human Ortholog: 15q24.1
Cellular Component:  mitochondrial inner membrane; mitochondrial matrix; mitochondrion
Molecular Function:  cholesterol monooxygenase (side-chain-cleaving) activity; heme binding; iron ion binding; protein binding
Biological Process:  C21-steroid hormone biosynthetic process; cellular response to peptide hormone stimulus; cholesterol metabolic process; cortisol metabolic process; glucocorticoid biosynthetic process; sterol metabolic process; vitamin D metabolic process
Disease: Adrenal Insufficiency, Congenital, With 46,xy Sex Reversal, Partial Or Complete
Reference #:  P05108 (UniProtKB)
Alt. Names/Synonyms: cholesterol 20-22 desmolase; Cholesterol desmolase; cholesterol monooxygenase (side-chain cleaving); Cholesterol side-chain cleavage enzyme, mitochondrial; CP11A; CYP11A; CYP11A1; CYPXIA1; Cytochrome P450 11A1; cytochrome P450 family 11 subfamily A member 1; cytochrome P450 family 11 subfamily A polypeptide 1; Cytochrome P450(scc); cytochrome P450, family 11, subfamily A, polypeptide 1; cytochrome P450, subfamily XIA (cholesterol side chain cleavage); cytochrome P450C11A1; P450SCC; steroid 20-22-lyase
Gene Symbols: CYP11A1
Molecular weight: 60,102 Da
Basal Isoelectric point: 8.89  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein