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SNCAIP
Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1. Detected in brain (at protein level). Widely expressed, with highest levels in brain, heart and placenta. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Vesicle |
| Chromosomal Location of human Ortholog: 5q23.2 |
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Cellular Component:
cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; neuronal cell body; nucleoplasm; presynaptic membrane; synaptic vesicle
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Molecular Function:
identical protein binding; protein binding; ubiquitin protein ligase binding
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Biological Process:
cell death; cellular protein metabolic process; dopamine metabolic process; regulation of inclusion body assembly; regulation of neurotransmitter secretion
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Disease: Parkinson Disease, Late-onset
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Reference #:
Q9Y6H5
(UniProtKB)
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Alt. Names/Synonyms: Alpha-synuclein-interacting protein; MGC39814; SNCAIP; SNCAP; Sph1; Synphilin-1; synuclein alpha interacting protein; synuclein, alpha interacting protein; SYPH1
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Gene Symbols: SNCAIP
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Molecular weight:
100,409 Da
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Basal Isoelectric point:
5.96
Predict pI for various phosphorylation states
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