SNCAIP Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1. Detected in brain (at protein level). Widely expressed, with highest levels in brain, heart and placenta. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of human Ortholog: 5q23.2
Cellular Component:  cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; neuronal cell body; nucleoplasm; presynaptic membrane; synaptic vesicle
Molecular Function:  identical protein binding; protein binding; ubiquitin protein ligase binding
Biological Process:  cell death; cellular protein metabolic process; dopamine metabolic process; regulation of inclusion body assembly; regulation of neurotransmitter secretion
Disease: Parkinson Disease, Late-onset
Reference #:  Q9Y6H5 (UniProtKB)
Alt. Names/Synonyms: Alpha-synuclein-interacting protein; MGC39814; SNCAIP; SNCAP; Sph1; Synphilin-1; synuclein alpha interacting protein; synuclein, alpha interacting protein; SYPH1
Gene Symbols: SNCAIP
Molecular weight: 100,409 Da
Basal Isoelectric point: 5.96  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein