matrin 3 May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. May bind to specific miRNA hairpins. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA processing; RNA-binding
Chromosomal Location of Human Ortholog: 18 B2|18 19.14 cM
Cellular Component:  cytoplasm; nuclear matrix; nucleus
Molecular Function:  identical protein binding; metal ion binding; miRNA binding; nucleic acid binding; RNA binding; zinc ion binding
Biological Process:  activation of innate immune response; blastocyst formation; heart valve development; immune system process; innate immune response; posttranscriptional regulation of gene expression; ventricular septum development
Reference #:  Q8K310 (UniProtKB)
Alt. Names/Synonyms: 1110061A14Rik; 2810017I02Rik; AI841759; AW555618; D030046F20Rik; Matr3; matrin 3; Matrin-3; mKIAA0723
Gene Symbols: Matr3
Molecular weight: 94,630 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Select Structure to View Below

matrin 3

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene