ARHGAP32 GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity. Belongs to the PX domain-containing GAP family. Isoform 1 and isoform 2 are highly expressed in brain and testis. Isoform 1 is also expressed in other tissues such as lung, liver and spleen. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Rac/Rho
Chromosomal Location of Human Ortholog: 9|9 A4
Cellular Component:  actin cytoskeleton; cell cortex; cell junction; cell projection; cytoplasm; endoplasmic reticulum; endosome; fibrillar center; Golgi apparatus; membrane; nucleoplasm; plasma membrane; postsynaptic density; postsynaptic membrane; synapse
Molecular Function:  GTPase activator activity; phosphatidylinositol binding; protein binding
Biological Process:  Rho protein signal transduction; signal transduction; small GTPase mediated signal transduction
Reference #:  Q811P8 (UniProtKB)
Alt. Names/Synonyms: 3426406O18Rik; Arhgap32; Brain-specific Rho GTPase-activating protein; GAB-associated CDC42; GAB-associated Cdc42/Rac GTPase-activating protein; GC-G; GC-GAP; Grit; GTPase-activating protein for Cdc42 and Rac1; Kiaa0712; mKIAA0712; p200R; p200RhoGAP; p250GAP; PX-; PX-RICS; rac GTPase activating protein; RHG32; Rho GTPase activating protein 32; Rho GTPase activating protein 33 pseudogene; Rho GTPase-activating protein; Rho GTPase-activating protein 32; Rho-type GTPase-activating protein 32; Rho/Cdc42/Rac GTPase-activating protein RICS; RhoGAP involved in the beta -catenin-N-cadherin and NMDA receptor signaling; RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling; Rics
Gene Symbols: Arhgap32
Molecular weight: 229,719 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene