CGN Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the cingulin family. Localized on the cytoplasmic face of tight junctions of polarized epithelia and some endothelia. Expressed in pancreas, kidney, liver and lung, but not in skeletal muscle, placenta, brain or heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of mouse Ortholog: 3 F2.1|3 40.74 cM
Cellular Component:  anchoring junction; apical junction complex; bicellular tight junction; brush border; cell junction; myosin complex; plasma membrane
Molecular Function:  microtubule binding; protein binding
Biological Process:  bicellular tight junction assembly; epithelial cell morphogenesis; microtubule cytoskeleton organization
Reference #:  P59242 (UniProtKB)
Alt. Names/Synonyms: 6330408J11Rik; AI647528; AI987749; Cgn; CING; Cingulin; Kiaa1319; MGC118157
Gene Symbols: Cgn
Molecular weight: 136,447 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein