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RALA
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells. During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody. Belongs to the small GTPase superfamily. Ras family. Note: This description may include information from UniProtKB.
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| Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 13 A2|13 6.05 cM |
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Cellular Component:
cell surface; cleavage furrow; cytoplasmic vesicle membrane; endocytic vesicle; focal adhesion; membrane; mitochondrion; plasma membrane; Schaffer collateral - CA1 synapse; synaptic membrane
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Molecular Function:
ATPase binding; Edg-2 lysophosphatidic acid receptor binding; G protein activity; GDP binding; GTP binding; GTPase activity; hydrolase activity; myosin binding; nucleotide binding; protein binding; ubiquitin protein ligase binding
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Biological Process:
cell cycle; cell division; establishment of protein localization to mitochondrion; exocytosis; membrane raft localization; neural tube closure; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of filopodium assembly; positive regulation of mitochondrial fission; Ras protein signal transduction; receptor internalization; regulation of actin cytoskeleton organization; regulation of exocytosis; regulation of postsynaptic neurotransmitter receptor internalization; signal transduction
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Reference #:
P63321
(UniProtKB)
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Alt. Names/Synonyms: 3010001O15Rik; AW322615; OTTMUSP00000018472; Ral; Ral-a; ral-A protein; Rala; RAS-like, family 1; Ras-related protein Ral-A; Rasl1; v-ral simian leukemia viral oncogene A (ras related); v-ral simian leukemia viral oncogene homolog A (ras related)
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Gene Symbols: Rala
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Molecular weight:
23,553 Da
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Basal Isoelectric point:
6.66
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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