RALA Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells. During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody. Belongs to the small GTPase superfamily. Ras family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7p14.1
Cellular Component:  cell surface; cleavage furrow; cytoplasmic vesicle membrane; Flemming body; plasma membrane
Molecular Function:  ATPase binding; Edg-2 lysophosphatidic acid receptor binding; GDP binding; GTP binding; GTPase activity; myosin binding; protein binding; ubiquitin protein ligase binding
Biological Process:  actin cytoskeleton reorganization; cell cycle; cell division; chemotaxis; exocytosis; interleukin-12-mediated signaling pathway; membrane organization; membrane raft localization; neural tube closure; positive regulation of filopodium assembly; Ras protein signal transduction; regulation of exocytosis; signal transduction
Disease: Hiatt-neu-cooper Neurodevelopmental Syndrome
Reference #:  P11233 (UniProtKB)
Alt. Names/Synonyms: MGC48949; RAL; RALA; RALA Ras like proto-oncogene A; Ras family small GTP binding protein RALA; RAS like proto-oncogene A; ras related GTP binding protein A; ras related v-ral simian leukemia viral oncogene homolog A; RAS-like protein A; Ras-related protein Ral-A; v-ral simian leukemia viral oncogene homolog A (ras related)
Gene Symbols: RALA
Molecular weight: 23,567 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB