UBR5 E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Nuclear receptor co-regulator; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 15|15 B3.1
Cellular Component:  cytosol; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein-containing complex
Molecular Function:  metal ion binding; protein binding; RNA binding; transferase activity; ubiquitin binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; ubiquitin-ubiquitin ligase activity; zinc ion binding
Biological Process:  cellular response to DNA damage stimulus; DNA repair; negative regulation of double-strand break repair; negative regulation of histone H2A K63-linked ubiquitination; negative regulation of interleukin-17 secretion; positive regulation of canonical Wnt signaling pathway; positive regulation of gene expression; positive regulation of protein import into nucleus; progesterone receptor signaling pathway; protein K48-linked ubiquitination; protein polyubiquitination; regulation of protein stability
Reference #:  Q80TP3 (UniProtKB)
Alt. Names/Synonyms: 4432411E13Rik; AW549941; C77315; D030042K14; E3 ubiquitin protein ligase, HECT domain containing, 1; E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase, HECT domain-containing 1; Edd; Edd1; extraembryonic development; Hyperplastic discs protein homolog; Kiaa0896; mKIAA0896; ubiquitin protein ligase E3 component n-recognin 5; Ubr5
Gene Symbols: Ubr5
Molecular weight: 308,352 Da
Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA