ADRB3 Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily. Expressed mainly in adipose tissues. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of mouse Ortholog: 8 A2|8 15.94 cM
Cellular Component:  membrane; nucleus; plasma membrane; receptor complex
Molecular Function:  adrenergic receptor activity; beta-3 adrenergic receptor binding; beta-adrenergic receptor activity; beta3-adrenergic receptor activity; epinephrine binding; G protein-coupled receptor activity; norepinephrine binding; protein homodimerization activity
Biological Process:  activation of adenylate cyclase activity; adenylate cyclase-activating adrenergic receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; brown fat cell differentiation; diet induced thermogenesis; eating behavior; G protein-coupled receptor signaling pathway; heat generation; negative regulation of multicellular organism growth; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure; positive regulation of cold-induced thermogenesis; positive regulation of MAPK cascade; response to cold; signal transduction
Reference #:  P25962 (UniProtKB)
Alt. Names/Synonyms: Adrb; Adrb-3; Adrb3; Adrb3r; adrenergic receptor, beta 3; B3bar; beta 3-AR; Beta-3 adrenergic receptor; Beta-3 adrenoceptor; Beta-3 adrenoreceptor; Beta-3 AR; beta3-adrenergic receptor
Gene Symbols: Adrb3
Molecular weight: 43,006 Da
Basal Isoelectric point: 9.57  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene