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ADRB3
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily. Expressed mainly in adipose tissues. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of human Ortholog: 8p11.23 |
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Cellular Component:
plasma membrane; receptor complex
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Molecular Function:
beta-3 adrenergic receptor binding; beta-adrenergic receptor activity; beta3-adrenergic receptor activity; epinephrine binding; norepinephrine binding; protein binding; protein homodimerization activity
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Biological Process:
activation of adenylate cyclase activity; adenylate cyclase-activating adrenergic receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; brown fat cell differentiation; carbohydrate metabolic process; desensitization of G protein-coupled receptor signaling pathway by arrestin; diet induced thermogenesis; eating behavior; energy reserve metabolic process; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; generation of precursor metabolites and energy; heat generation; negative regulation of multicellular organism growth; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure; positive regulation of cold-induced thermogenesis; positive regulation of MAPK cascade; receptor-mediated endocytosis; response to cold
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Disease: Obesity
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Reference #:
P13945
(UniProtKB)
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Alt. Names/Synonyms: ADRB3; ADRB3R; adrenergic, beta-3-, receptor; adrenoceptor beta 3; B3AR; Beta-3 adrenergic receptor; Beta-3 adrenoceptor; Beta-3 adrenoreceptor; BETA3AR; FLJ99960
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Gene Symbols: ADRB3
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Molecular weight:
43,519 Da
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Basal Isoelectric point:
9.39
Predict pI for various phosphorylation states
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