TAF2 Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter. Belongs to the TAF2 family. Note: This description may include information from UniProtKB.
Protein type: Transcription initiation complex
Chromosomal Location of Human Ortholog: 8q24.12
Cellular Component:  nucleoplasm; transcription factor TFIID complex; transcription factor TFTC complex
Molecular Function:  protein binding; TFIID-class transcription factor complex binding; transcription regulatory region DNA binding
Biological Process:  G2/M transition of mitotic cell cycle; positive regulation of transcription by RNA polymerase II; regulation of signal transduction by p53 class mediator; response to organic cyclic compound; transcription by RNA polymerase II; transcription initiation from RNA polymerase II promoter
Disease: Mental Retardation, Autosomal Recessive 40
Reference #:  Q6P1X5 (UniProtKB)
Alt. Names/Synonyms: 150 kDa cofactor of initiator function; CIF150; cofactor of initiator function, 150kD subunit; RNA polymerase II TBP-associated factor subunit B; TAF(II)150; TAF2; TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa; TAF2B; TAFII-150; TAFII150; TATA box binding protein (TBP)-associated factor, RNA polymerase II, B, 150kD; TBP-associated factor 150 kDa; Transcription initiation factor TFIID 150 kDa subunit; Transcription initiation factor TFIID subunit 2
Gene Symbols: TAF2
Molecular weight: 136,971 Da
Basal Isoelectric point: 8.45  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene