NOC2L Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. Belongs to the NOC2 family. Note: This description may include information from UniProtKB.
Protein type: Histone-binding; Nucleolus; RNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 1p36.33
Cellular Component:  chromosome; cytosol; Noc1p-Noc2p complex; Noc2p-Noc3p complex; nucleolus; nucleoplasm; nucleus
Molecular Function:  chromatin binding; DNA-binding transcription factor binding; histone binding; nucleosome binding; protein binding; transcription corepressor activity
Biological Process:  apoptotic process; cellular response to UV; negative regulation of B cell apoptotic process; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of transcription by RNA polymerase II; ribosomal large subunit biogenesis; transcription initiation-coupled chromatin remodeling
Reference #:  Q9Y3T9 (UniProtKB)
Alt. Names/Synonyms: DKFZp564C186; FLJ35172; NET15; NET7; NIR; NOC2 like nucleolar associated transcriptional repressor; NOC2-like protein; NOC2L; NOC2L nucleolar associated transcriptional repressor; novel INHAT (inhibitor of histone acetyltransferase) repressor; Novel INHAT repressor; nucleolar complex associated 2 homolog; nucleolar complex associated 2 homolog (S. cerevisiae); Nucleolar complex protein 2 homolog; PPP1R112; Protein NOC2 homolog; protein phosphatase 1, regulatory subunit 12
Gene Symbols: NOC2L
Molecular weight: 84,919 Da
Basal Isoelectric point: 5.46  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein