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EPPK1
Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture. However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization. Belongs to the plakin or cytolinker family. Expressed in epithelial cells of liver, small intestine, colon, salivary glands, stomach and appendix. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 15|15 D3 |
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Cellular Component:
apicolateral plasma membrane; basal part of cell; bicellular tight junction; cell junction; cell periphery; cell projection; cell-cell junction; cytoplasm; cytoskeleton; hemidesmosome; intermediate filament cytoskeleton; keratin filament; membrane; perinucleolar compartment; plasma membrane
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Molecular Function:
cytoskeletal protein binding; intermediate filament binding; keratin filament binding; structural molecule activity
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Biological Process:
cytoskeleton organization; intermediate filament bundle assembly; intermediate filament cytoskeleton organization; intermediate filament organization; negative regulation of cell migration; negative regulation of epithelial cell proliferation; negative regulation of keratinocyte migration; negative regulation of keratinocyte proliferation; negative regulation of wound healing; positive regulation of epithelial cell proliferation involved in wound healing; regulation of epithelial cell differentiation; regulation of epithelium regeneration; wound healing
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Reference #:
Q8R0W0
(UniProtKB)
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Alt. Names/Synonyms: 6230424I18Rik; EPIPL; EPIPL1; Epiplakin; epiplakin 1; EPPK; Eppk1
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Gene Symbols: Eppk1
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Molecular weight:
724,737 Da
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Basal Isoelectric point:
5.74
Predict pI for various phosphorylation states
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