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DDX23
Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.4.13; Helicase; RNA processing; RNA splicing; RNA-binding; Spliceosome |
| Chromosomal Location of human Ortholog: 12q13.12 |
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Cellular Component:
catalytic step 2 spliceosome; chromatin; nucleolus; nucleoplasm; nucleus; U4/U6 x U5 tri-snRNP complex; U5 snRNP
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Molecular Function:
ATP binding; ATP hydrolysis activity; helicase activity; protein binding; RNA binding; RNA helicase activity
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Biological Process:
cis assembly of pre-catalytic spliceosome; mRNA splicing, via spliceosome; R-loop processing; RNA splicing; RNA splicing, via transesterification reactions
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Reference #:
Q9BUQ8
(UniProtKB)
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Alt. Names/Synonyms: 100 kDa U5 snRNP-specific protein; DDX23; DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; DEAD box protein 23; DEAD-box helicase 23; MGC8416; Probable ATP-dependent RNA helicase DDX23; prp28; PRP28 homolog; PRP28 homolog, yeast; PRP28p homolog; PRPF28; SNRNP100; U5 snRNP 100 kD protein; U5-100K; U5-100kD
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Gene Symbols: DDX23
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Molecular weight:
95,583 Da
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Basal Isoelectric point:
9.58
Predict pI for various phosphorylation states
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