GTF2F1 TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; EC; GTF2F1 family; Kinase, protein; Transcription initiation complex
Chromosomal Location of mouse Ortholog: 17|17 D
Cellular Component:  cell junction; intracellular membrane-bounded organelle; nucleus; protein-containing complex; transcription factor TFIID complex
Molecular Function:  DNA binding; phosphatase activator activity; promoter-specific chromatin binding; protein binding; protein domain specific binding; protein phosphatase binding; RNA polymerase II general transcription initiation factor activity; transcription factor binding
Biological Process:  negative regulation of protein binding; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter
Reference #:  Q3THK3 (UniProtKB)
Alt. Names/Synonyms: 2810405L04Rik; C76800; general transcription factor IIF polypeptide 1 (74kD subunit); General transcription factor IIF subunit 1; General transcription factor IIF, polypeptide 1; General transcription factor IIF, polypeptide 1, isoform CRA_c; Gtf2f1; RAP74; T2FA; TFIIF-alpha; transcription initiation factor IIF subunit alpha
Gene Symbols: Gtf2f1
Molecular weight: 57,241 Da
Basal Isoelectric point: 6.6  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene