GTF2F1 TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; EC; GTF2F1 family; Kinase, protein; Transcription initiation complex
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component:  cell junction; intracellular membrane-bounded organelle; nucleoplasm; nucleus; protein-containing complex; transcription factor TFIID complex; transcription factor TFIIF complex
Molecular Function:  DNA binding; phosphatase activator activity; promoter-specific chromatin binding; protein binding; protein domain specific binding; protein phosphatase binding; RNA polymerase II general transcription initiation factor activity; transcription coactivator activity; transcription factor binding
Biological Process:  7-methylguanosine mRNA capping; fibroblast growth factor receptor signaling pathway; mRNA splicing, via spliceosome; negative regulation of protein binding; positive regulation of catalytic activity; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of viral transcription; response to virus; RNA metabolic process; snRNA transcription by RNA polymerase II; transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter
Reference #:  P35269 (UniProtKB)
Alt. Names/Synonyms: BTF4; General transcription factor IIF 74 kDa subunit; General transcription factor IIF subunit 1; general transcription factor IIF, polypeptide 1, 74kDa; GTF2F1; RAP74; T2FA; TF2F1; TFIIF; TFIIF-alpha; Transcription initiation factor IIF subunit alpha; Transcription initiation factor RAP74
Gene Symbols: GTF2F1
Molecular weight: 58,240 Da
Basal Isoelectric point: 7.04  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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