EPS8L2 Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells. Belongs to the EPS8 family. Detected in fibroblasts and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; GEF; GEF, Rac/Rho
Chromosomal Location of mouse Ortholog: 7|7 F5
Cellular Component:  cell projection; centrosome; cytoplasm; cytosol; plasma membrane; protein-containing complex; ruffle; ruffle membrane; stereocilium bundle; stereocilium tip
Molecular Function:  actin binding; actin filament binding; guanyl-nucleotide exchange factor activity
Biological Process:  positive regulation of ruffle assembly; Rac protein signal transduction; regulation of Rho protein signal transduction; Rho protein signal transduction; sensory perception of sound
Reference #:  Q99K30 (UniProtKB)
Alt. Names/Synonyms: AI042819; AW545405; Epidermal growth factor receptor kinase substrate 8-like protein 2; epidermal growth factor receptor pathway substrate 8-like protein 2; Epidermal growth factor receptor pathway substrate 8-related protein 2; EPS8 related protein 2; EPS8-like 2; EPS8-like protein 2; EPS8-related protein 2; Eps8l2; Eps8r2; ES8L2; OTTMUSP00000029403
Gene Symbols: Eps8l2
Molecular weight: 82,229 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene