EPS8L2 Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells. Belongs to the EPS8 family. Detected in fibroblasts and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; GEF; GEF, Rac/Rho
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component:  cytosol; plasma membrane; protein-containing complex; ruffle membrane; stereocilium bundle; stereocilium tip
Molecular Function:  actin binding; protein binding
Biological Process:  positive regulation of ruffle assembly; regulation of Rho protein signal transduction; Rho protein signal transduction; sensory perception of sound
Disease: Deafness, Autosomal Recessive 106
Reference #:  Q9H6S3 (UniProtKB)
Alt. Names/Synonyms: DFNB106; Epidermal growth factor receptor kinase substrate 8-like protein 2; Epidermal growth factor receptor pathway substrate 8-related protein 2; EPS8 like 2; EPS8-like 2; EPS8-like protein 2; EPS8-related protein 2; EPS8L2; EPS8R2; ES8L2; FLJ16738; FLJ21935; FLJ22171; MGC126530; MGC3088
Gene Symbols: EPS8L2
Molecular weight: 80,621 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB