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SLC39A8
Acts as a manganese and zinc influx transporter. Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain. Belongs to the ZIP transporter (TC 2.A.5) family. Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
| Chromosomal Location of Human Ortholog: 3 G3|3 63.04 cM |
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Cellular Component:
integral component of membrane; integral component of plasma membrane; membrane; organelle membrane; plasma membrane
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Molecular Function:
metal ion transmembrane transporter activity; zinc ion transmembrane transporter activity
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Biological Process:
cadmium ion transmembrane transport; cellular zinc ion homeostasis; ion transport; metal ion transport; transmembrane transport; zinc ion import across plasma membrane; zinc ion transport
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Reference #:
Q91W10
(UniProtKB)
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Alt. Names/Synonyms: 4933419D20Rik; AA986696; BIGM10; BIGM103; Metal cation symporter ZIP8; OTTMUSP00000029071; OTTMUSP00000029072; S39A8; Slc39a8; solute carrier family 39 (metal ion transporter), member 8; Solute carrier family 39 member 8; Zinc transporter ZIP8; ZIP-8; Zip8; Zrt- and Irt-like protein 8
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Gene Symbols: Slc39a8
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Molecular weight:
50,082 Da
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Basal Isoelectric point:
5.52
Predict pI for various phosphorylation states
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