H1B Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family. Ubiquitous. Expressed in the majority of the cell lines tested and in testis. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 13|13 A3.1
Cellular Component:  chromosome; nuclear chromatin; nuclear euchromatin; nucleosome; nucleus
Molecular Function:  DNA binding; double-stranded DNA binding; nucleosomal DNA binding; protein binding
Biological Process:  chromosome condensation; muscle organ development; negative regulation of chromatin silencing; negative regulation of DNA recombination; nucleosome assembly; nucleosome positioning; regulation of transcription, DNA-templated
Reference #:  P43276 (UniProtKB)
Alt. Names/Synonyms: H1 histone family, member 5; H1 VAR.5; H1-5; H1.5; H15; H1b; H1f5; H1s-3; Hist1h1b; histone 1, family 5; histone 1, H1b; histone cluster 1, H1b; Histone H1.5; OTTMUSP00000000650
Gene Symbols: H1-5
Molecular weight: 22,576 Da
Basal Isoelectric point: 10.91  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene