H1B Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family. Ubiquitous. Expressed in the majority of the cell lines tested and in testis. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of human Ortholog: 6p22.1
Cellular Component:  chromatin; chromosome; heterochromatin; nucleolus; nucleoplasm; nucleosome; nucleus
Molecular Function:  chromatin DNA binding; double-stranded DNA binding; histone deacetylase binding; nucleosomal DNA binding; protein binding; structural constituent of chromatin
Biological Process:  chromatin organization; chromosome condensation; establishment of protein localization to chromatin; muscle organ development; negative regulation of DNA recombination; negative regulation of transcription by RNA polymerase II; nucleosome assembly; protein stabilization
Reference #:  P16401 (UniProtKB)
Alt. Names/Synonyms: H1; H1 histone family, member 5; H1-5; H1.5; H1.5 linker histone, cluster member; H15; H1B; H1F5; H1s-3; HIST1H1B; histone 1, H1b; histone cluster 1 H1 family member b; histone cluster 1, H1b; Histone H1.5; Histone H1a; Histone H1b; Histone H1s-3; MGC126630; MGC126632
Gene Symbols: H1-5
Molecular weight: 22,580 Da
Basal Isoelectric point: 10.91  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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