SLC39A7 transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2011]
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 6p21.32
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; integral component of membrane; membrane; nucleoplasm
Molecular Function:  protein binding; zinc ion transmembrane transporter activity
Reference #:  Q92504 (UniProtKB)
Alt. Names/Synonyms: D6S115E; D6S2244E; H2-KE4; Histidine-rich membrane protein Ke4; HKE4; HLA class II region expressed gene KE4; KE4; Ke4 gene, mouse, human homolog of; Really interesting new gene 5 protein; RING5; S39A7; SLC39A7; solute carrier family 39 (zinc transporter), member 7; Solute carrier family 39 member 7; Zinc transporter SLC39A7; ZIP7
Gene Symbols: SLC39A7
Molecular weight: 50,118 Da
Basal Isoelectric point: 6.36  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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