PDCL3 Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination. Belongs to the phosducin family. Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 1|1 B
Cellular Component:  cytoplasm; cytosol; nucleus
Molecular Function:  protein binding involved in protein folding; vascular endothelial growth factor receptor 2 binding
Biological Process:  angiogenesis; apoptotic process; negative regulation of ubiquitin-dependent protein catabolic process; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; regulation of peptidyl-tyrosine phosphorylation
Reference #:  Q8BVF2 (UniProtKB)
Alt. Names/Synonyms: 1110061A19Rik; C80025; IAP-associated factor VIAF1; Pdcl3; phosducin-like 3; Phosducin-like protein 3; VIAF-1; Viaf1; Viral IAP-associated factor 1
Gene Symbols: Pdcl3
Molecular weight: 27,581 Da
Basal Isoelectric point: 4.66  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene