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PDCL3
Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination. Belongs to the phosducin family. Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis |
| Chromosomal Location of human Ortholog: 2q11.2 |
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Cellular Component:
cytoplasm; cytosol; endoplasmic reticulum; nucleoplasm; perinuclear region of cytoplasm; perinucleolar compartment; protein-containing complex
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Molecular Function:
protein binding; protein folding chaperone; vascular endothelial growth factor receptor 2 binding
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Biological Process:
actin cytoskeleton organization; angiogenesis; apoptotic process; chaperone-mediated protein folding; negative regulation of chaperone-mediated protein folding; negative regulation of ubiquitin-dependent protein catabolic process; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; positive regulation of gene expression; protein folding; protein stabilization; regulation of peptidyl-tyrosine phosphorylation
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Reference #:
Q9H2J4
(UniProtKB)
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Alt. Names/Synonyms: HTPHLP; IAP-associated factor VIAF1; MGC3062; PDCL3; PHLP2A; PHLP3; phosducin like 3; phosducin-like 3; Phosducin-like protein 3; PhPL3; VIAF; VIAF-1; VIAF1; Viral IAP-associated factor 1
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Gene Symbols: PDCL3
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Molecular weight:
27,614 Da
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Basal Isoelectric point:
4.78
Predict pI for various phosphorylation states
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