API5 Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Belongs to the API5 family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; RNA-binding
Chromosomal Location of Human Ortholog: 2|2 E1
Cellular Component:  cytoplasm; nuclear speck; nucleus; spliceosomal complex
Molecular Function:  fibroblast growth factor binding
Biological Process:  apoptotic process; negative regulation of apoptotic process; negative regulation of fibroblast apoptotic process
Reference #:  O35841 (UniProtKB)
Alt. Names/Synonyms: AAC-11; AI196452; API-5; Api5; Apoptosis inhibitor 5; apoptosis inhibitory protein 5; OTTMUSP00000015342
Gene Symbols: Api5
Molecular weight: 56,785 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene