|
GTF2F2
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. Belongs to the TFIIF beta subunit family. Note: This description may include information from UniProtKB.
|
| Protein type: EC 3.6.4.12; Helicase; Nuclear receptor co-regulator; Transcription initiation complex |
| Chromosomal Location of mouse Ortholog: 14|14 D3 |
|
Cellular Component:
microtubule cytoskeleton; nucleoplasm; nucleus; transcription factor TFIIF complex; transcription factor TFIIH holo complex
|
|
Molecular Function:
DNA binding; protein binding; RNA polymerase II general transcription initiation factor activity
|
|
Biological Process:
positive regulation of transcription by RNA polymerase II; RNA polymerase II preinitiation complex assembly; transcription by RNA polymerase II; transcription elongation by RNA polymerase II; transcription initiation at RNA polymerase II promoter
|
|
Reference #:
Q8R0A0
(UniProtKB)
|
|
Alt. Names/Synonyms: 1110031C13Rik; AI326315; ATP-dependent helicase GTF2F2; General transcription factor IIF subunit 2; general transcription factor IIF, polypeptide 2; Gtf2f2; T2FB; TFIIF-beta; Transcription initiation factor IIF subunit beta
|
|
Gene Symbols: Gtf2f2
|
|
Molecular weight:
28,381 Da
|
|
Basal Isoelectric point:
9.23
Predict pI for various phosphorylation states
|
|
CST Pathways:
Protein Acetylation
|
