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GTF2F2
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. Belongs to the TFIIF beta subunit family. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.4.12; Helicase; Nuclear receptor co-regulator; Transcription initiation complex |
| Chromosomal Location of Human Ortholog: 14|14 D3 |
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Cellular Component:
microtubule cytoskeleton; nucleus; transcription factor TFIIF complex; transcription factor TFIIH holo complex; transcriptional preinitiation complex
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Molecular Function:
ATP binding; DNA binding; helicase activity; hydrolase activity; nucleotide binding; protein binding
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Biological Process:
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation from RNA polymerase II promoter; transcription by RNA polymerase II; transcription initiation from RNA polymerase II promoter
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Reference #:
Q8R0A0
(UniProtKB)
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Alt. Names/Synonyms: 1110031C13Rik; AI326315; ATP-dependent helicase GTF2F2; General transcription factor IIF subunit 2; general transcription factor IIF, polypeptide 2; Gtf2f2; T2FB; TFIIF-beta; Transcription initiation factor IIF subunit beta
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Gene Symbols: Gtf2f2
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Molecular weight:
28,381 Da
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Basal Isoelectric point:
9.23
Predict pI for various phosphorylation states
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CST Pathways:
Protein Acetylation
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