GTF2F2 TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. Belongs to the TFIIF beta subunit family. Note: This description may include information from UniProtKB.
Protein type: EC; Helicase; Nuclear receptor co-regulator; Transcription initiation complex
Chromosomal Location of Human Ortholog: 13q14.12-q14.13
Cellular Component:  microtubule cytoskeleton; nucleoplasm; nucleus; transcriptional preinitiation complex
Molecular Function:  ATP binding; DNA binding; helicase activity; protein binding
Biological Process:  7-methylguanosine mRNA capping; fibroblast growth factor receptor signaling pathway; mRNA splicing, via spliceosome; positive regulation of transcription by RNA polymerase II; positive regulation of viral transcription; RNA metabolic process; snRNA transcription by RNA polymerase II; transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter
Reference #:  P13984 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase GTF2F2; BTF4; General transcription factor IIF 30 kDa subunit; General transcription factor IIF subunit 2; general transcription factor IIF, polypeptide 2, 30kDa; GTF2F2; RAP30; T2FB; TF2F2; TFIIF; TFIIF-beta; Transcription initiation factor IIF subunit beta; Transcription initiation factor RAP30
Gene Symbols: GTF2F2
Molecular weight: 28,380 Da
Basal Isoelectric point: 9.24  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
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Protein Structure Not Found.

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