|
Siglec-9
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils). Found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain, stomach, lung, thymus, prostate, brain, mammary, adrenal gland, colon, trachea, cerebellum, testis, small intestine and spinal cordon. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Membrane protein, integral; Receptor, misc. |
| Chromosomal Location of Human Ortholog: 19q13.41 |
|
Cellular Component:
integral component of plasma membrane; plasma membrane; secretory granule membrane
|
|
Molecular Function:
carbohydrate binding; protein binding
|
|
Biological Process:
cell adhesion; cell surface receptor signaling pathway; neutrophil degranulation; regulation of immune response
|
|
Reference #:
Q9Y336
(UniProtKB)
|
|
Alt. Names/Synonyms: CD329; CDw329; OB binding protein-like; OBBP-LIKE; Protein FOAP-9; sialic acid binding Ig-like lectin 9; Sialic acid-binding Ig-like lectin 9; SIGL9; Siglec-9; SIGLEC9
|
|
Gene Symbols: SIGLEC9
|
|
Molecular weight:
50,082 Da
|
|
Basal Isoelectric point:
6.86
Predict pI for various phosphorylation states
|
|
| Select Structure to View Below |
Siglec-9
|
|
|