Siglec-9 Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils). Found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain, stomach, lung, thymus, prostate, brain, mammary, adrenal gland, colon, trachea, cerebellum, testis, small intestine and spinal cordon. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of human Ortholog: 19q13.41
Cellular Component:  integral component of plasma membrane; plasma membrane; secretory granule membrane
Molecular Function:  carbohydrate binding; protein binding
Biological Process:  cell adhesion; cell surface receptor signaling pathway; neutrophil degranulation; regulation of immune response
Reference #:  Q9Y336 (UniProtKB)
Alt. Names/Synonyms: CD329; CDw329; FOAP-9; OB binding protein-like; OBBP-LIKE; Protein FOAP-9; sialic acid binding Ig like lectin 9; sialic acid binding Ig-like lectin 9; Sialic acid-binding Ig-like lectin 9; SIGL9; Siglec-9; SIGLEC9
Gene Symbols: SIGLEC9
Molecular weight: 50,082 Da
Basal Isoelectric point: 6.86  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene