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TNRC6B
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. Belongs to the GW182 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA-binding |
| Chromosomal Location of mouse Ortholog: 15|15 E1 |
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Cellular Component:
cytoplasm; nucleoplasm; P-body
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Molecular Function:
nucleic acid binding; RNA binding
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Biological Process:
miRNA-mediated gene silencing; miRNA-mediated gene silencing by inhibition of translation; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; regulation of translation; regulatory ncRNA-mediated gene silencing
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Reference #:
NP_796098
(RefSeq)
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Alt. Names/Synonyms: 2700090M07Rik; A730065C02Rik; AI848765; D230019K20Rik; Kiaa1093; MGC28739; TNR6B; Tnrc6b; trinucleotide repeat containing 6b; Trinucleotide repeat-containing gene 6B protein
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Gene Symbols: Tnrc6b
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Molecular weight:
191,963 Da
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Basal Isoelectric point:
5.91
Predict pI for various phosphorylation states
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