TNRC6B Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. Belongs to the GW182 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of mouse Ortholog: 15|15 E1
Cellular Component:  cytoplasm; nucleoplasm; P-body
Molecular Function:  nucleic acid binding; RNA binding
Biological Process:  miRNA-mediated gene silencing; miRNA-mediated gene silencing by inhibition of translation; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; regulation of translation; RNA-mediated gene silencing
Reference #:  NP_796098 (RefSeq)
Alt. Names/Synonyms: 2700090M07Rik; A730065C02Rik; AI848765; D230019K20Rik; Kiaa1093; MGC28739; TNR6B; Tnrc6b; trinucleotide repeat containing 6b; Trinucleotide repeat-containing gene 6B protein
Gene Symbols: Tnrc6b
Molecular weight: 188,047 Da
Basal Isoelectric point: 6.36  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene