|
TNRC6B
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. Belongs to the GW182 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: RNA-binding |
| Chromosomal Location of mouse Ortholog: 15|15 E1 |
|
Cellular Component:
cytoplasm; nucleoplasm; P-body
|
|
Molecular Function:
nucleic acid binding; RNA binding
|
|
Biological Process:
miRNA-mediated gene silencing; miRNA-mediated gene silencing by inhibition of translation; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; regulation of translation; RNA-mediated gene silencing
|
|
Reference #:
NP_796098
(RefSeq)
|
|
Alt. Names/Synonyms: 2700090M07Rik; A730065C02Rik; AI848765; D230019K20Rik; Kiaa1093; MGC28739; TNR6B; Tnrc6b; trinucleotide repeat containing 6b; Trinucleotide repeat-containing gene 6B protein
|
|
Gene Symbols: Tnrc6b
|
|
Molecular weight:
188,047 Da
|
|
Basal Isoelectric point:
6.36
Predict pI for various phosphorylation states
|
