TNRC6B Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. Belongs to the GW182 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of human Ortholog: 22q13.1
Cellular Component:  cytosol
Molecular Function:  protein binding
Biological Process:  gene silencing by RNA; miRNA mediated inhibition of translation; negative regulation of gene expression; positive regulation of gene expression; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; posttranscriptional gene silencing by RNA; regulation of megakaryocyte differentiation; Wnt signaling pathway, calcium modulating pathway
Disease: Global Developmental Delay With Speech And Behavioral Abnormalities
Reference #:  Q9UPQ9 (UniProtKB)
Alt. Names/Synonyms: KIAA1093; TNR6B; TNRC6B; trinucleotide repeat containing 6B; trinucleotide repeat containing adaptor 6B; Trinucleotide repeat-containing gene 6B protein
Gene Symbols: TNRC6B
Molecular weight: 194,002 Da
Basal Isoelectric point: 6.31  Predict pI for various phosphorylation states
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TNRC6B

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein