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TNRC6B
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. Belongs to the GW182 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA-binding |
| Chromosomal Location of human Ortholog: 22q13.1 |
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Cellular Component:
cytosol; nucleoplasm; P-body
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Molecular Function:
protein binding
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Biological Process:
miRNA-mediated gene silencing; miRNA-mediated gene silencing by inhibition of translation; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; RNA-mediated gene silencing
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Disease: Global Developmental Delay With Speech And Behavioral Abnormalities
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Reference #:
Q9UPQ9
(UniProtKB)
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Alt. Names/Synonyms: KIAA1093; TNR6B; TNRC6B; trinucleotide repeat containing 6B; trinucleotide repeat containing adaptor 6B; Trinucleotide repeat-containing gene 6B protein
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Gene Symbols: TNRC6B
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Molecular weight:
194,002 Da
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Basal Isoelectric point:
6.31
Predict pI for various phosphorylation states
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