MYO1E Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. Defects in MYO1E are the cause of focal segmental glomerulosclerosis type 6 (FSGS6). A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. FSGS6 is a childhood-onset disorder resulting in nephrotic syndrome, which includes massive proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 15q22.2
Cellular Component:  actin cytoskeleton; adherens junction; brush border; cell-cell junction; cytoplasm; cytoskeleton; myosin complex
Molecular Function:  actin filament binding; ATP binding; ATPase activity, coupled; calmodulin binding; microfilament motor activity; motor activity; phosphatidylinositol binding; protein binding
Biological Process:  actin filament-based movement; endocytosis; glomerular basement membrane development; glomerular filtration; glomerular visceral epithelial cell development; in utero embryonic development; nitrogen compound metabolic process; platelet-derived growth factor receptor signaling pathway; post-embryonic hemopoiesis; vasculogenesis
Disease: Focal Segmental Glomerulosclerosis 6
Reference #:  Q12965 (UniProtKB)
Alt. Names/Synonyms: HuncM-IC; MGC104638; MYO1C; MYO1E; MYO1E variant protein; myosin IE; Myosin-Ic; Myosin-Ie; Unconventional myosin-Ie
Gene Symbols: MYO1E
Molecular weight: 127,062 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB