CMPK Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. Ubiquitously expressed. 3 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Kinase, other; Nucleotide Metabolism - pyrimidine
Chromosomal Location of mouse Ortholog: 4|4 D1
Cellular Component:  cytoplasm; nucleolus; nucleus
Molecular Function:  ATP binding; CMP kinase activity; cytidylate kinase activity; kinase activity; nucleobase-containing compound kinase activity; nucleoside diphosphate kinase activity; nucleotide binding; transferase activity; uridylate kinase activity
Biological Process:  'de novo' pyrimidine nucleobase biosynthetic process; CDP biosynthetic process; dCDP biosynthetic process; dUDP biosynthetic process; nucleobase-containing compound metabolic process; nucleoside diphosphate phosphorylation; nucleoside triphosphate biosynthetic process; phosphorylation; pyrimidine nucleotide biosynthetic process; UDP biosynthetic process
Reference #:  Q9DBP5 (UniProtKB)
Alt. Names/Synonyms: 0610011D08Rik; Cmk; Cmp; Cmpk; Cmpk1; cytidine monophosphate (UMP-CMP) kinase 1; Cytidine monophosphate kinase; Cytidylate kinase; cytidylate kinase 1; dCMP kinase; Deoxycytidylate kinase; KCY; likely ortholog of H. sapiens UMP-CMP kinase (UMP-CMPK); Nucleoside-diphosphate kinase; OTTMUSP00000008931; Uck; Umk; UMP-CMP kinase; UMP-CMPk; UMP/CMP kinase; UMP/CMPK; Umpk; Uridine monophosphate kinase; Uridine monophosphate/cytidine monophosphate kinase
Gene Symbols: Cmpk1
Molecular weight: 22,165 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene