CMPK Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. Ubiquitously expressed. 3 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.4.14; EC 2.7.4.6; Kinase, other; Nucleotide Metabolism - pyrimidine
Chromosomal Location of Human Ortholog: 1p33
Cellular Component:  cytoplasm; cytosol; nucleolus; nucleus
Molecular Function:  ATP binding; cytidylate kinase activity; nucleoside diphosphate kinase activity; uridine kinase activity; uridylate kinase activity
Biological Process:  'de novo' pyrimidine nucleobase biosynthetic process; nucleobase-containing small molecule interconversion; nucleoside diphosphate phosphorylation; nucleoside monophosphate phosphorylation; nucleoside triphosphate biosynthetic process; pyrimidine ribonucleotide biosynthetic process; UMP biosynthetic process
Reference #:  P30085 (UniProtKB)
Alt. Names/Synonyms: CK; CMK; CMPK; CMPK1; cytidine monophosphate (UMP-CMP) kinase 1, cytosolic; Cytidine monophosphate kinase; cytidine/uridine monophosphate kinase 1; Cytidylate kinase; dCMP kinase; Deoxycytidylate kinase; KCY; Nucleoside-diphosphate kinase; UCK; UMK; UMP-CMP kinase; UMP-CMPK; UMP/CMP kinase; UMP/CMPK; UMPK; Uridine monophosphate kinase; Uridine monophosphate/cytidine monophosphate kinase
Gene Symbols: CMPK1
Molecular weight: 22,222 Da
Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states
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CMPK

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene