|
CMPK
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. Ubiquitously expressed. 3 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: EC 2.7.4.14; EC 2.7.4.6; Kinase, other; Nucleotide Metabolism - pyrimidine |
| Chromosomal Location of human Ortholog: 1p33 |
|
Cellular Component:
cytoplasm; cytosol; nucleolus; nucleoplasm; nucleus
|
|
Molecular Function:
ATP binding; CMP kinase activity; cytidylate kinase activity; dCMP kinase activity; nucleoside diphosphate kinase activity; nucleoside monophosphate kinase activity; UMP kinase activity; uridine kinase activity
|
|
Biological Process:
'de novo' pyrimidine nucleobase biosynthetic process; CDP biosynthetic process; nucleobase-containing small molecule interconversion; nucleoside monophosphate phosphorylation; phosphorylation; pyrimidine ribonucleotide biosynthetic process; UDP biosynthetic process; UMP biosynthetic process
|
|
Reference #:
P30085
(UniProtKB)
|
|
Alt. Names/Synonyms: CK; CMK; CMPK; CMPK1; cytidine monophosphate (UMP-CMP) kinase 1, cytosolic; Cytidine monophosphate kinase; cytidine/uridine monophosphate kinase 1; Cytidylate kinase; dCMP kinase; Deoxycytidylate kinase; KCY; Nucleoside-diphosphate kinase; UCK; UMK; UMP-CMP kinase; UMP-CMPK; UMP/CMP kinase; UMP/CMPK; UMPK; Uridine monophosphate kinase; Uridine monophosphate/cytidine monophosphate kinase
|
|
Gene Symbols: CMPK1
|
|
Molecular weight:
22,222 Da
|
|
Basal Isoelectric point:
5.44
Predict pI for various phosphorylation states
|
