LST1 Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation. Belongs to the LST1 family. Expressed in lung, tonsil, thymus, placenta, kidney, fetal spleen, fetal liver and brain. 13 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Membrane protein, integral
Chromosomal Location of human Ortholog: 6p21.33
Cellular Component:  cytoplasm; cytosol; Golgi apparatus; Golgi membrane; membrane; plasma membrane
Biological Process:  anatomical structure morphogenesis; cell morphogenesis; dendrite development; immune response; negative regulation of lymphocyte proliferation; regulation of cell shape
Reference #:  O00453 (UniProtKB)
Alt. Names/Synonyms: B144; D6S49E; leucocyte specific transcript 1; leukocyte specific transcript 1; Leukocyte-specific transcript 1 protein; LST-1; LST1; lymphocyte antigen 117; MGC119006; MGC119007; Protein B144
Gene Symbols: LST1
Molecular weight: 10,792 Da
Basal Isoelectric point: 8.43  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein