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PIEZO1
Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology. Belongs to the PIEZO (TC 1.A.75) family. Expressed in numerous tissues. In normal brain, expressed exclusively in neurons, not in astrocytes. In Alzheimer disease brains, expressed in about half of the activated astrocytes located around classical senile plaques. In Parkinson disease substantia nigra, not detected in melanin-containing neurons nor in activated astrocytes. Expressed in erythrocytes (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 16q24.3 |
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Cellular Component:
endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; lamellipodium membrane; plasma membrane
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Molecular Function:
mechanosensitive monoatomic ion channel activity; monoatomic cation channel activity; protein binding
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Biological Process:
cellular response to mechanical stimulus; detection of mechanical stimulus; monoatomic cation transmembrane transport; monoatomic cation transport; positive regulation of cell-cell adhesion mediated by integrin; positive regulation of integrin activation; positive regulation of myotube differentiation; regulation of membrane potential
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Disease: Blood Group, Er; Dehydrated Hereditary Stomatocytosis With Or Without Pseudohyperkalemia And/or Perinatal Edema; Lymphedema, Hereditary, Iii
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Reference #:
Q92508
(UniProtKB)
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Alt. Names/Synonyms: DHS; FA38A; FAM38A; family with sequence similarity 38, member A; KIAA0233; LMPH3; LMPHM6; Membrane protein induced by beta-amyloid treatment; Mib; PIEZ1; piezo type mechanosensitive ion channel component 1; Piezo-type mechanosensitive ion channel component 1; PIEZO1; Protein FAM38A
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Gene Symbols: PIEZO1
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Molecular weight:
286,790 Da
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Basal Isoelectric point:
7.37
Predict pI for various phosphorylation states
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