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MYO1G
Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. Minor histocompatibility antigen HA-2: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Specifically expressed in hematopoietic cells. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Contractile; Motor |
| Chromosomal Location of mouse Ortholog: 11|11 A1 |
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Cellular Component:
actin cytoskeleton; cell projection; cytoplasm; filopodium; lamellipodium; leading edge membrane; membrane; microvillus; myosin complex; nucleoplasm; phagocytic cup; plasma membrane; vesicle
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Molecular Function:
actin binding; actin filament binding; ATP binding; calmodulin binding; cytoskeletal motor activity; lipid binding; microfilament motor activity; nucleotide binding; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding
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Biological Process:
actin filament organization; adaptive immune response; cell gliding; cell-substrate adhesion; establishment of localization in cell; exocytosis; Fc-gamma receptor signaling pathway involved in phagocytosis; immune system process; phagocytosis; T cell meandering migration; T cell mediated immunity; vesicle transport along actin filament
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Reference #:
Q5SUA5
(UniProtKB)
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Alt. Names/Synonyms: E430002D17Rik; Myo1g; myosin 1G; myosin IG; Myosin-Ig; OTTMUSP00000005332; Unconventional myosin-Ig
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Gene Symbols: Myo1g
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Molecular weight:
117,227 Da
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Basal Isoelectric point:
8.83
Predict pI for various phosphorylation states
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