MYO1G Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. Minor histocompatibility antigen HA-2: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Specifically expressed in hematopoietic cells. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Contractile; Motor
Chromosomal Location of Human Ortholog: 7p13
Cellular Component:  filopodium; lamellipodium; leading edge membrane; microvillus; myosin complex; phagocytic cup; plasma membrane
Molecular Function:  actin binding; ATP binding; calmodulin binding; motor activity; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding
Biological Process:  cell gliding; cell-substrate adhesion; exocytosis; Fc-gamma receptor signaling pathway involved in phagocytosis; T cell meandering migration; T cell mediated immunity; T cell migration
Reference #:  B0I1T2 (UniProtKB)
Alt. Names/Synonyms: HA2; MGC142104; MHAG; mHag HA-2; Minor histocompatibility antigen HA-2; MYO1G; myosin IG; Myosin-Ig; Unconventional myosin-Ig
Gene Symbols: MYO1G
Molecular weight: 116,442 Da
Basal Isoelectric point: 8.96  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB