ETEA Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis. Broadly expressed, with highest levels in brain. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Ubiquitin conjugating system
Chromosomal Location of human Ortholog: 5q35.2
Cellular Component:  azurophil granule lumen; endoplasmic reticulum; extracellular region; lipid droplet; VCP-NPL4-UFD1 AAA ATPase complex
Molecular Function:  lipase binding; lipase inhibitor activity; protein binding; ubiquitin binding; ubiquitin protein ligase binding
Biological Process:  lipid droplet organization; response to unfolded protein; retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway
Reference #:  Q96CS3 (UniProtKB)
Alt. Names/Synonyms: ETEA; expressed in T-cells and eosinophils in atopic dermatitis; FAF2; Fas associated factor family member 2; FAS-associated factor 2; KIAA0887; Protein ETEA; UBX domain containing 8; UBX domain protein 3B; UBX domain-containing protein 3B; UBX domain-containing protein 8; UBXD8; UBXN3B
Gene Symbols: FAF2
Molecular weight: 52,623 Da
Basal Isoelectric point: 5.46  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein