DIP Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response. Expressed in lung and in primary lung squamous cell carcinoma (LSCC). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of mouse Ortholog: 15|15 E2
Cellular Component:  endoplasmic reticulum; integral component of membrane; membrane; mitochondrion
Molecular Function:  protein binding
Biological Process:  apoptotic process; negative regulation of toll-like receptor 9 signaling pathway; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Reference #:  Q8CB44 (UniProtKB)
Alt. Names/Synonyms: 9930016O13; Death-inducing protein; Dip; GRAM domain containing 4; GRAM domain-containing protein 4; GRAM4; Gramd4; Kiaa0767; OTTMUSP00000031292
Gene Symbols: Gramd4
Molecular weight: 72,264 Da
Basal Isoelectric point: 9.17  Predict pI for various phosphorylation states
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DIP

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene