GAB3 a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: 
Biological Process:  macrophage differentiation
Reference #:  Q8WWW8 (UniProtKB)
Alt. Names/Synonyms: DOS/Gab family member 3; GAB3; Gab3 scaffolding protein; GRB2-associated binder 3; GRB2-associated binding protein 3; GRB2-associated-binding protein 3; Growth factor receptor bound protein 2-associated protein 3
Gene Symbols: GAB3
Molecular weight: 65,589 Da
Basal Isoelectric point: 6.8  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein