DPH6 Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide. Belongs to the Diphthine--ammonia ligase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC
Chromosomal Location of Human Ortholog: 15q14
Cellular Component:  cytosol; nucleolus; nucleus
Molecular Function:  ATP binding; diphthine-ammonia ligase activity
Biological Process:  peptidyl-diphthamide biosynthetic process from peptidyl-histidine
Reference #:  Q7L8W6 (UniProtKB)
Alt. Names/Synonyms: ATP binding domain 4; ATP-binding domain-containing protein 4; ATPBD4; Diphthamide synthase; Diphthamide synthetase; diphthamine biosynthesis 6; Diphthine--ammonia ligase; DPH6; DPH6 homolog; Protein DPH6 homolog
Gene Symbols: DPH6
Molecular weight: 30,307 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB