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DPH6
Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide. Belongs to the Diphthine--ammonia ligase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 6.3.1.14 |
| Chromosomal Location of human Ortholog: 15q14 |
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Cellular Component:
cytosol
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Molecular Function:
ATP binding; diphthine-ammonia ligase activity
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Biological Process:
peptidyl-diphthamide biosynthetic process from peptidyl-histidine
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Reference #:
Q7L8W6
(UniProtKB)
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Alt. Names/Synonyms: ATP binding domain 4; ATP-binding domain-containing protein 4; ATPBD4; Diphthamide synthase; Diphthamide synthetase; diphthamine biosynthesis 6; Diphthine--ammonia ligase; DPH6; DPH6 homolog; Protein DPH6 homolog
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Gene Symbols: DPH6
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Molecular weight:
30,307 Da
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Basal Isoelectric point:
5.24
Predict pI for various phosphorylation states
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