UBE1L Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein. Belongs to the ubiquitin-activating E1 family. Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 9 F1|9 59.07 cM
Cellular Component:  cytoplasm; nucleus
Molecular Function:  ISG15 activating enzyme activity; ubiquitin-protein transferase activity
Biological Process:  cellular protein modification process; cellular response to DNA damage stimulus; ISG15-protein conjugation; modification-dependent protein catabolic process; protein modification by small protein conjugation
Reference #:  Q9DBK7 (UniProtKB)
Alt. Names/Synonyms: 1300004C08Rik; MCG18845, isoform CRA_d; Uba7; Ube1l; ubiquitin activating enzyme E1-like; Ubiquitin-activating enzyme E1-like; ubiquitin-like modifier activating enzyme 7
Gene Symbols: Uba7
Molecular weight: 108,679 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
Select Structure to View Below

UBE1L

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene