XRN1 Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA. Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). Belongs to the 5'-3' exonuclease family. Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.11.-; RNA-binding; Ribonuclease; Tumor suppressor
Chromosomal Location of Human Ortholog: 9|9 E3.3
Cellular Component:  cytoplasm; cytosol; dendrite; neuronal cell body; P-body; plasma membrane; synapse
Molecular Function:  5'-3' exonuclease activity; 5'-3' exoribonuclease activity; DNA binding; exonuclease activity; G-quadruplex DNA binding; G-quadruplex RNA binding; hydrolase activity; nuclease activity; nucleic acid binding; protein binding; RNA binding
Biological Process:  cell aging; histone mRNA catabolic process; meiotic cell cycle; negative regulation of translation; nuclear mRNA surveillance; nuclear-transcribed mRNA catabolic process; RNA phosphodiester bond hydrolysis, exonucleolytic; RNA processing; rRNA catabolic process; telomere maintenance
Reference #:  P97789 (UniProtKB)
Alt. Names/Synonyms: 5'-3' exoribonuclease 1; Dhm2; Exo; mXRN1; Protein Dhm2; Sep1; Strand-exchange protein 1 homolog; Xrn1
Gene Symbols: Xrn1
Molecular weight: 194,307 Da
Basal Isoelectric point: 7.23  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene