XRN1 Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA. Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). Belongs to the 5'-3' exonuclease family. Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.11.-; RNA-binding; Ribonuclease; Tumor suppressor
Chromosomal Location of Human Ortholog: 3q23
Cellular Component:  cytosol; dendrite; neuronal cell body; nucleus; P-body; plasma membrane; synapse
Molecular Function:  5'-3' exoribonuclease activity; G-quadruplex DNA binding; G-quadruplex RNA binding; protein binding; telomerase RNA binding
Biological Process:  cellular response to cycloheximide; cellular response to puromycin; histone mRNA catabolic process; negative regulation of telomere maintenance via telomerase; negative regulation of translation; nuclear mRNA surveillance; nuclear-transcribed mRNA catabolic process; regulation of mRNA stability; response to testosterone; RNA phosphodiester bond hydrolysis, exonucleolytic; rRNA catabolic process
Reference #:  Q8IZH2 (UniProtKB)
Alt. Names/Synonyms: 5'-3' exoribonuclease 1; DKFZp434P0721; DKFZp686B22225; DKFZp686F19113; FLJ41903; SEP1; Strand-exchange protein 1 homolog; XRN1
Gene Symbols: XRN1
Molecular weight: 194,107 Da
Basal Isoelectric point: 6.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein