PLD3
May be involved in APP processing. Belongs to the phospholipase D family. Widely expressed. In the brain, high levels of expression are detected in the frontal, temporal and occipital cortices and hippocampus. Expressed at low level in corpus callosum. Note: This description may include information from UniProtKB.
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Protein type: EC 3.1.4.4; Endoplasmic reticulum; Membrane protein, integral; Phospholipase |
Chromosomal Location of human Ortholog: 19q13.2 |
Cellular Component:
early endosome membrane; endoplasmic reticulum membrane; Golgi membrane; late endosome membrane; lysosomal lumen; lysosomal membrane
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Molecular Function:
phospholipase D activity; protein binding; single-stranded DNA 5'-3' DNA exonuclease activity
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Biological Process:
DNA metabolic process; immune system process; inflammatory response; myotube differentiation; regulation of cytokine production involved in inflammatory response
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Disease: Spinocerebellar Ataxia 46
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Reference #:
Q8IV08
(UniProtKB)
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Alt. Names/Synonyms: 5'-3' exonuclease PLD3; AD19; Choline phosphatase 3; HindIII K4L homolog; Hu-K4; HUK4; Phosphatidylcholine-hydrolyzing phospholipase D3; phospholipase D family member 3; phospholipase D family, member 3; Phospholipase D3; PLD 3; PLD3; SCA46
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Gene Symbols: PLD3
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Molecular weight:
54,705 Da
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Basal Isoelectric point:
6.02
Predict pI for various phosphorylation states
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