PLD3 May be involved in APP processing. Belongs to the phospholipase D family. Widely expressed. In the brain, high levels of expression are detected in the frontal, temporal and occipital cortices and hippocampus. Expressed at low level in corpus callosum. Note: This description may include information from UniProtKB.
Protein type: EC; Endoplasmic reticulum; Membrane protein, integral; Phospholipase
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component:  endoplasmic reticulum membrane; integral component of membrane
Molecular Function:  N-acylphosphatidylethanolamine-specific phospholipase D activity; phospholipase D activity; protein binding
Biological Process:  lipid catabolic process
Disease: Spinocerebellar Ataxia 46
Reference #:  Q8IV08 (UniProtKB)
Alt. Names/Synonyms: Choline phosphatase 3; HindIII K4L homolog; Hu-K4; HUK4; Phosphatidylcholine-hydrolyzing phospholipase D3; phospholipase D family, member 3; Phospholipase D3; PLD 3; PLD3
Gene Symbols: PLD3
Molecular weight: 54,705 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein