PLD3 May be involved in APP processing. Belongs to the phospholipase D family. Widely expressed. In the brain, high levels of expression are detected in the frontal, temporal and occipital cortices and hippocampus. Expressed at low level in corpus callosum. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.4; Endoplasmic reticulum; Membrane protein, integral; Phospholipase
Chromosomal Location of human Ortholog: 19q13.2
Cellular Component:  early endosome membrane; endoplasmic reticulum membrane; Golgi membrane; late endosome membrane; lysosomal lumen; lysosomal membrane
Molecular Function:  phospholipase D activity; protein binding; single-stranded DNA 5'-3' DNA exonuclease activity
Biological Process:  DNA metabolic process; immune system process; inflammatory response; myotube differentiation; regulation of cytokine production involved in inflammatory response
Disease: Spinocerebellar Ataxia 46
Reference #:  Q8IV08 (UniProtKB)
Alt. Names/Synonyms: 5'-3' exonuclease PLD3; AD19; Choline phosphatase 3; HindIII K4L homolog; Hu-K4; HUK4; Phosphatidylcholine-hydrolyzing phospholipase D3; phospholipase D family member 3; phospholipase D family, member 3; Phospholipase D3; PLD 3; PLD3; SCA46
Gene Symbols: PLD3
Molecular weight: 54,705 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
Select Structure to View Below

PLD3

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein