DOCK11 Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42. Belongs to the DOCK family. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: X|X A3.3
Cellular Component: 
Molecular Function:  guanyl-nucleotide exchange factor activity; Rho GTPase binding; Rho guanyl-nucleotide exchange factor activity
Biological Process:  B cell homeostasis; marginal zone B cell differentiation; positive regulation of filopodium assembly; positive regulation of GTPase activity; small GTPase mediated signal transduction
Reference #:  A2AF47 (UniProtKB)
Alt. Names/Synonyms: 5033414A21Rik; 8030476J24; ACG; Activated Cdc42-associated guanine nucleotide exchange factor; dedicator of cytokinesis 11; Dedicator of cytokinesis protein 11; DOC11; Dock11; OTTMUSP00000018699; sph238; spleen specific 238 kDa protein with PH domain; Ziz2; Zizi; Zizimin-2; Zizimin2
Gene Symbols: Dock11
Molecular weight: 237,771 Da
Basal Isoelectric point: 7.94  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene