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coronin 1A
May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. Belongs to the WD repeat coronin family. Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 7 69.25 cM|7 F3 |
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Cellular Component:
actin cytoskeleton; actin filament; axon; cell leading edge; cell-cell junction; cortical actin cytoskeleton; cytoplasm; cytoplasmic vesicle; cytoskeleton; early endosome; glutamatergic synapse; immunological synapse; lamellipodium; membrane; phagocytic cup; phagocytic vesicle; plasma membrane; protein-containing complex; stereocilium tip; synapse
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Molecular Function:
actin binding; actin filament binding; actin monomer binding; cytoskeletal protein binding; identical protein binding; myosin heavy chain binding; phosphatidylinositol 3-kinase binding; protein binding; protein homodimerization activity
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Biological Process:
actin cytoskeleton organization; actin filament organization; calcium ion transport; cell migration; cell-substrate adhesion; cellular response to interleukin-4; early endosome to recycling endosome transport; epithelial cell migration; establishment of localization in cell; homeostasis of number of cells within a tissue; leukocyte chemotaxis; natural killer cell degranulation; negative regulation of actin nucleation; negative regulation of neuron apoptotic process; negative regulation of vesicle fusion; nerve growth factor signaling pathway; neuron apoptotic process; phagocytosis; phagolysosome assembly; positive chemotaxis; positive regulation of T cell activation; positive regulation of T cell migration; positive regulation of T cell proliferation; regulation of actin cytoskeleton organization; regulation of actin filament polymerization; regulation of actin polymerization or depolymerization; regulation of cell shape; regulation of release of sequestered calcium ion into cytosol; response to cytokine; T cell activation; T cell homeostasis; T cell migration; T cell proliferation; thymocyte migration; uropod organization; vesicle fusion
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Reference #:
O89053
(UniProtKB)
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Alt. Names/Synonyms: Clabp; Clipin-A; COR1A; Coro1; Coro1a; coronin 1; coronin 1a; coronin, actin binding protein 1A; Coronin-1A; coronin-like actin binding protein; Coronin-like protein A; Coronin-like protein p57; Lmb; Lmb3; OTTMUSP00000030348; OTTMUSP00000030349; p57; TACO; Tryptophan aspartate-containing coat protein
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Gene Symbols: Coro1a
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Molecular weight:
50,989 Da
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Basal Isoelectric point:
6.05
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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