DFNA5 Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53. Gasdermin-E, N-terminal: Switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis. Produced by the cleavage of GSDME by CASP3, perforates cell membrane and thereby induces pyroptosis. After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate. Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents. Exhibits bactericidal activity. Belongs to the gasdermin family. Expressed in cochlea. Low level of expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas, with highest expression in placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor
Chromosomal Location of mouse Ortholog: 6|6 B2.3
Cellular Component:  cytoplasm; cytosol; membrane; plasma membrane
Molecular Function:  cardiolipin binding; phosphatidylinositol-4,5-bisphosphate binding; wide pore channel activity
Biological Process:  cell death; cellular response to tumor necrosis factor; cellular response to virus; granzyme-mediated programmed cell death signaling pathway; inner ear auditory receptor cell differentiation; negative regulation of cell population proliferation; positive regulation of immune response to tumor cell; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of MAPK cascade; programmed cell death; pyroptosis; sensory perception of sound
Reference #:  Q9Z2D3 (UniProtKB)
Alt. Names/Synonyms: 2310037D07Rik; 4932441K13Rik; deafness associated tumor suppressor; deafness, autosomal dominant 5 (human); deafness, autosomal dominant 5 homolog; Dfn; Dfna; Dfna5; Dfna5h; EG14210; Fin; Fin15; gasdermin E; Gasdermin-E; Gasdermin-E, C-terminal; Gasdermin-E, N-terminal; Gsdme; GSDME-CT; GSDME-NT; Non-syndromic hearing impairment protein 5 homolog; nonsyndromic hearing impairment protein
Gene Symbols: Gsdme
Molecular weight: 56,631 Da
Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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DFNA5

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein