4E-T Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Karyopherin; Nuclear import; Translation
Chromosomal Location of mouse Ortholog: 11 A1|11 2.24 cM
Cellular Component:  cytoplasm; cytosol; intracellular membrane-bounded organelle; nucleus; P-body
Molecular Function:  mRNA binding; nuclear export signal receptor activity; protein binding
Biological Process:  negative regulation of neuron differentiation; negative regulation of translation; protein transport; stem cell population maintenance
Reference #:  Q9EST3 (UniProtKB)
Alt. Names/Synonyms: 2610509L04Rik; 4E-T; 4ET; A930019J01Rik; AA410001; AU021239; Cla; Clast4; D11Ertd166; D11Ertd166e; eIF4E transporter; Eif4enif1; Eukaryotic translation initiation factor 4E nuclear import factor 1; Eukaryotic translation initiation factor 4E transporter; OTTMUSP00000005193
Gene Symbols: Eif4enif1
Molecular weight: 107,986 Da
Basal Isoelectric point: 7.4  Predict pI for various phosphorylation states
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4E-T

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene